You should be able to do this today. Setup the Application.xml the same way vods3 is setup with the following MediaReader section:
Code:
<MediaReader>
<Properties>
<Property>
<Name>randomAccessReaderClass</Name>
<Value>com.wowza.wms.plugin.amazonaws.ec2.mediacache.MediaCacheRandomAccessReaderAmazonEC2</Value>
</Property>
<Property>
<Name>bufferSeekIO</Name>
<Value>true</Value>
<Type>Boolean</Type>
</Property>
</Properties>
</MediaReader>
Then just use the stream names as you would to stream from S3. It should all just work.
Charlie